功能基因组学实验室 Functional Genomics Lab

点击次数：

研究室负责人(PI)：田小利教授，博士生导师，南昌大学人类衰老研究所所长

科技部973项目首席科学家，科技部重点研发计划项目负责人，江西省“人类衰老重点实验室主任”，江西省创新创业高层次人才“千人计划”入选者。本研究室拟运用群体遗传学和模式动物等手段，寻找和研究血管衰老及衰老相关心脑血管疾病的遗传机制，期望通过延缓衰老从而控制心脑血管疾病的发生和发展。Aging Cell 杂志的 supervising editor; BioEssay杂志的编委；发表SCI文章70余篇，包括Nature, Circulation, Human Molecular Genetics等。目前是Circulation等 20 余杂志的审稿人。

邮箱：tianxiaoli@ncu.edu.cn, tian.xiaoli@163.com

科技部重大研究计划973 项目“血管衰老的生物学基础”首席，研究领域围绕遗传、血管和衰老；从基因的发现到功能鉴定。主要通过群体遗传学方法寻找和确定人类衰老相关基因，然后研究它们在心血管疾病中的重要机制。

教育经历:

1999-2004：美国克里福兰临床中心 (Cleveland Clinic Foundation) 博士后

1995-1999：德国柏林自由大学 (Berlin Free University) 博士学位

1991-1994：北京协和医科大学硕士学位

1983-1987：武汉大学生物系生化专业学士学位

工作经历:

2016至今 南昌大学生命科学学院、人类衰老研究所，教授

2006-2016  北京大学分子医学研究所人类群体遗传室，教授

2004-2006: 美国克里福兰临床中心 (Cleveland Clinic Foundation), Staff Research Associate

1999-2004：美国克里福兰临床中心 (Cleveland Clinic Foundation) 博士后

1994-1999：德国柏林 “Hypertension Research, Max-Delbruck Center for Molecular Medicine”, 访问学者

1992-1994：北京阜外医院生化室，助理研究员

1987-1992：北京阜外医院生化室，实习研究员

专业学会任职：

1) 中国生理学会衰老与健康专业委员会候任主委

2) 中国老年学和老年医学学会老年病学基础医学专家委员会主任委员

3) 中国老年医学研究机构联盟副主任委员

4) 中华医学会老年医学分会老年基础医学学组委员

5) 中国老年学学会衰老与抗衰老科学委员会常务委员

6) 中国老年保健医学研究会老年健康与转化医学分会常务委员

7) 中国老年学和老年医学学会抗衰老分会常务委员

8) 中国老年学和老年医学学会老年病学副会长

9) 华中科技大学分子生物物理教育部重点实验室第三届学术委员会委员

10) 中山大学眼科国家重点实验室第三届学术委员会委员

11) 国家老年医学中心学术委员会委员

12) 首届中国生物医药整合联盟常务理事

13) 中国人类遗传资源管理专家组成员

14) 国家自然基金委二审专家

承担的科研题目及经费

1) 2024.1-2028.12：项目负责人，国家自然基金委重点项目“染色体促长寿基因簇互作减缓动脉粥样硬化的分子机制”（82330046,220万）

2) 2023.12-2026.11：课题负责人，国家科技部重点研发计划“组织器官衰老顺序影响个体亚健康及疾病的机制”（2023YFC3603301,285万）

3) 2020.1-2024.12：项目负责人，国家科技部重点研发计划“营养、运动对老年健康的影响和干预作用”（2020YFC2002900，1700万）。

4) 2019.1-2022.12: 课题负责人，江西省重点研发计划--重点项目“冠心病相关基因的遗传筛查及个体化治疗评估体系的建立"（20192ACB70002，100万）。

5) 2018.1-2020.12：课题负责人，江西省科技厅重点项目“百岁老人逸脱冠心病的遗传机制”（20181ACB20017，50万）

6) 2018.1-2022.12：课题负责人，江西省“人类衰老重点实验室”主任（20181BCD40001，50万）

7) 2017.1-2022.12: 课题负责人，国家自然基金重点项目“个体衰老相关基因调节血管衰老的分子机制” （81630034，275万）

8) 2013.1-2017.8：首席，科技部973计划“血管衰老及相关疾病的生物学基础”（2013CB530700)

9) 2012.1-2016.12:课题负责人，国家自然基金重点项目“血管损伤早期应答和启动修复保护的信号转导机制以及通过AGGF1干预的可能性研究”（81130003）

10) 2011.1-2013.12：课题负责人，国家自然基金面上项目“血管新生因子AGGF1新异构体的功能鉴定”(81070262)

11) 2007-2011：课题负责人，科技部973项目分题（2007CB512103)“缺血性心脏病的分子遗传学基础”（973项目“重大心脏疾病分子机理和干预策略的基础研究”）

12) 2007-2010：课题负责人，国家自然基金重点项目（30730047）“血管生成因子在血管发育畸形和瘤变中的分子调控机制”

横向基金

1) Ancestry-dependent genetic association with coronary artery diseases (100,000$), AstraZeneca, Sweden （2011-2014）

2) Pathway-enriched genetic variants and atherosclerosis (81,000$), Bayer, Germany （2014-2015）

3) Identification of Novel Drug Targets for Liver Cancer and Rheumatoid Arthritis (100,000$), Amgen, U.S.A. （2013-2015）

编委：

Aging Cell ； BioEssays ； Molecular Genetics and Genomics ； Genes ,  Frontier in Endocrinology ； Heart and Circulation

教学工作

研究生：

南昌大学，复杂性状与遗传（四个课时／学期）

北京大学，疾病与遗传（48个课时／学期，主讲人）

中科院大学，遗传与疾病（两个课时／学期）

本科生：

北京大学：

遗传与疾病（两个课时／学期）

群体遗传学及进化（两个课时／学期）

南昌大学：

· 长寿与遗传（四个课时／学期）

获奖及专利：

获奖：

1) 遗传与衰老参与冠心病发生发展的分子机制；江西省自然科学二等奖；获奖年度：2020；第一完成单位：南昌大学；主要完成人：田小利（南昌大学），陶伟（北京大学），倪挺（复旦大学）。

2) 获2004年克里夫兰临床中心分子心脏学室最佳论文艾文-培基奖（The Irvine H. Page Award for best Publication, 2003-2004, The Cleveland Clinic Foundation,   注：Page是已故世界著名高血压专家，克里夫兰临床中心的奠基人）。

3) 2000年获克里夫兰临床中心分子心脏学室伯纳玎 • 海莉奖 (The Bernadine Healy Award，注：Healy是世界著名心脏专家，红十字协会主席)；

4) 2000年美国心脏学会年会优秀摘要奖  (AHA Scientific Session Abstract Award)。

5) 1996年获中国教育部先进科技成果奖“肾素基因转基因及其技术的探索”（乙，代码96-176，主要完成人）

6) 1995年获中国教育部先进科技成果奖“脂肪族两亲物和心血管药物影响肌浆网钙泵、膜质及蛋白构象的研究”（乙，代码95-197，第四完成人）

专利：

1) 田小利，李扬。一种分离的RNASEK基因及其在制备抗血管衰老药物中的应用, 2020-08-25, 中国, ZL201610536970.2

2) 田小利，李扬。THSD7A基因序列及表达改变检测及其在冠心病预测中的应用, 2018-03-27, 中国, ZL201510029413.7

3) 田小利， 李扬。SCML4基因序列及表达改变检测及其在冠心病预测中的应用, 2017-12-15, 中国, ZL201510029012.1

4) 田小利，李扬。 miR-375抑制剂在制备抗血管衰老药物中的应用, 2016-06-21, 中国, CN201610451300.0

5) 田小利， 胡方园， 张勇。蛋白质AGGF1及其FHA多肽在制备抗炎药物中的应用, 2015-03-25, 中国, ZL201310157027.7

6) 田小利，向阳，闫晗，陈胜寒，李恒，李扬。支链氨基酸代谢相关基因SNV、测定试剂及其用途, 2019-01-31, 中国, CN201910100122.0

7) 向阳，邹鑫，田小利等。 PAR1抑制剂在制备用于防治内皮细胞衰老的产品中的应用，2021-05-31, 中国, 202110599783.X

8) 向阳，秦嘉蔚，周晶，孙素姣，田小利，陈胜寒，段晶晶，张慧杰。野菊花内酯作为制备秀丽隐杆线虫抗应激药物或延长寿命药物中的应用, 2020-07-08,中国,CN202010653078.9

9) 用定位克隆技术发现了一个新的调节血管新生的基因VG5Q (现命名为AGGF1)，为解释血管新生及相关疾病的发生机制及基因治疗提供了重要基础 （Nature, 2004）。OMIM：608464。此研究申报美国专利一项 （PCT/US2004/027324）

主要发表文章（*通讯作者）

1. Xu W, Liu X, Han W, Wu K, Zhao M, Mei T, Shang B, Wu J, Luo J, Lai Y, Yang B, Zhuo Y, Lu L, Liu Y, Tian XL, Zhao L*. Inhibiting HIF-1 signaling alleviates HTRA1-induced RPE senescence in retinal degeneration.  Cell Commun Signal. 2023 Jun 14;21(1):134. doi: 10.1186/s12964-023-01138-9.

2. Jie Ren, Moshi Song, Weiqi Zhang, Jian-Ping Cai, Feng Cao, Zhongwei Cao, Piu Chan, Chang Chen  , Guobing Chen, Hou-Zao Chen, Jun Chen, Xiao-Chun Chen, Weimin Ci, Bi-Sen Ding , Qiurong Ding, Feng Gao, Shaorong Gao, Jing-Dong J Han, Qi-Yang He, Kai Huang, Zhenyu Ju, Qing-Peng Kong, Ji Li, Jian Li, Jingyi Li, Xin Li, Baohua Liu, Feng Liu, Jun-Ping Liu, Lin Liu, Qiang Liu, Qiang Liu, Xingguo Liu, Yong Liu, Xianghang Luo, Shuai Ma, Xinran Ma, Zhiyong Mao, Jing Nie, Yaojin Peng, Jing Qu, Ruibao Ren, Weihong Song, Zhou Songyang, Liang Sun, Yi Eve Sun, Yu Sun, Mei Tian, Xiao-Li Tian, Ye Tian, Jianwei Wang, Shusen Wang, Si Wang, Wengong Wang, Xia Wang, Xiaoning Wang, Yan-Jiang Wang, Yunfang Wang, Catherine C L Wong, Andy Peng Xiang, Yichuan Xiao, Zhi-Xiong Xiao, Zhengwei Xie, Wei Xiong, Daichao Xu, Ze Yang, Jing Ye, Wei Yu, Rui Yue, Cuntai Zhang, Hongbo Zhang, Liang Zhang, Xinchao Zhang, Yong Zhang, Yun-Wu Zhang, Zhuohua Zhang, Tongbiao Zhao, Yuzheng Zhao, Zhongjun Zhou, Dahai Zhu , Weiguo Zou, Gang Pei, Guang-Hui Liu. The Aging Biomarker Consortium represents a new era for aging research in China.  Nat Med . 2023 Jul 19.  doi: 10.1038/s41591-023-02444-y.  Online ahead of print.

3. Cai Y, Song W, Li J, Jing Y, Liang C, Zhang L, Zhang X, Zhang W, Liu B, An Y, Li J, Tang B, Pei S, Wu X, Liu Y, Zhuang CL, Ying Y, Dou X, Chen Y, Xiao FH, Li D, Yang R, Zhao Y, Wang Y, Wang L, Li Y, Ma S, Wang S, Song X, Ren J, Zhang L, Wang J, Zhang W, Xie Z, Qu J, Wang J, Xiao Y, Tian Y, Wang G, Hu P, Ye J, Sun Y, Mao Z, Kong QP, Liu Q, Zou W, Tian XL, Xiao ZX, Liu Y, Liu JP, Song M, Han JJ, Liu GH. The landscape of aging.  Sci China Life Sci. 2022 Dec;65(12):2354-2454. doi: 10.1007/s11427-022-2161-3. Epub 2022 Sep 2.

4. Liu H, Liu J, Long C, Chen L, Zhan W, Xiao W, Gong X, Liu M, Tian XL, Chen S. Lack of NPR1 Increases Vascular Endothelial Adhesion through Induction of Integrin Beta 4.  Int J Mol Sci  . 2022 Oct 20;23(20):12627. doi: 10.3390/ijms232012627.

5. Shuangjin Ding, Jiankun Liu, XiaoRui Han, Wanqiu Ding, Zhirui Liu, Ying Zhu, Wenxing Zhan, Yiqi Wan, Shujie Gai, Junjie Hou, Xiaoxia Wang, Yixia Wu, Andong Wu, Chuan-Yun Li, Zhe Zheng, Xiao-Li Tian*, Huiqing Cao* ICAM-1-Related Noncoding RNA accelerates atherosclerosis by amplifying NF-κB signaling,  JMCC , 2022(accepted)

6. Wan Y, Liu Z, Wu A, Khan AH, Zhu Y, Ding S, Li X, Zhao Y, Dai X, Zhou J, Liu J, Li Y, Gong X, Liu M, Tian XL*. Hyperglycemia Promotes Endothelial Cell Senescence through AQR/PLAU Signaling Axis.  Int J Mol Sci . 2022 Mar 7;23(5):2879. doi: 10.3390/ijms23052879.

7. Zhang CF, Wang HM, Wu A, Li Y and Tian XL*. FHA domain of AGGF1 is essential for its nucleocytoplasmic transport and angiogenesis.  Science China Life sciences . 2021.

8. Zhang C, Zhang X, Huang L, Guan Y, Huang X, Tian XL, Zhang L and Tao W. ATF3 drives senescence by reconstructing accessible chromatin profiles.  Aging cell . 2021;20:e13315.

9. Sun ZC, Jiang Z, Xu X, Li M, Zeng Q, Zhu Y, Wang S, Li Y, Tian XL* and Hu C*. Fish Paralog Proteins RNASEK-a and -b Enhance Type I Interferon Secretion and Promote Apoptosis.  Frontiers in immunology . 2021;12:762162.

10. Li Y, Yan H, Guo J, Han Y, Zhang C, Liu X, Du J and Tian XL*. Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease.  Cardiovasc Res . 2021;117:240-255.

11. Zhu Y, Liang Y, Khan AH, Dong M, Wan Y, Sun Z, Zeng Y, Nie C and Tian XL*. Allelic distribution of ABO gene in Chinese centenarians.  Aging Med (Milton). 2020;3:195-204.

12. Zhang WH, Liu WZ, He Y, You WJ, Zhang JY, Xu H, Tian XL, Li BM, Mei L, Holmes A and Pan BX. Chronic Stress Causes Projection-Specific Adaptation of Amygdala Neurons via Small-Conductance Calcium-Activated Potassium Channel Downregulation.  Biological psychiatry . 2019;85:812-828.

13. Zhang JY, Liu TH, He Y, Pan HQ, Zhang WH, Yin XP, Tian XL, Li BM, Wang XD, Holmes A, Yuan TF and Pan BX. Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner.  Biological psychiatry . 2019;85:189-201.

14. Yao Y, Jiang C, Wang F, Yan H, Long D, Zhao J, Wang J, Zhang C, Li Y, Tian XL, Wang QK, Wu G and Zhang Z. Integrative Analysis of miRNA and mRNA Expression Profiles Associated With Human Atrial Aging.  Frontiers in physiology . 2019;10:1226.

15. Sun Z, Khan AH and Tian XL*. Atherosclerosis. In: D. Gu and M. E. Dupre, eds.  Encyclopedia of Gerontology and Population Aging Cham: Springer International Publishing; 2019: 1-10.

16. Shi SZ, Lee EJ, Lin YJ, Chen L, Zheng HY, He XQ, Peng JY, Noonepalle SK, Shull AY, Pei FC, Deng LB, Tian XL, Deng KY, Shi H and Xin HB. Recruitment of monocytes and epigenetic silencing of intratumoral CYP7B1 primarily contribute to the accumulation of 27-hydroxycholesterol in breast cancer . American journal of cancer research . 2019;9:2194-2208.

17. Saeed M and Tian XL*. Cardiovascular System. In: D. Gu and M. E. Dupre, eds.  Encyclopedia of Gerontology and Population Aging Cham: Springer International Publishing; 2019: 1-11.

18. Saeed M and Tian XL*. Circulatory System. In: D. Gu and M. E. Dupre, eds.  Encyclopedia of Gerontology and Population Aging Cham: Springer International Publishing; 2019: 1-8.

19. Li H, Wang X, Lu X, Zhu H, Li S, Duan S, Zhao X, Zhang F, Alterovitz G, Wang F, Li Q, Tian XL* and Xu M*. Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice.  Aging (Albany NY). 2019;11:7620-7638.

20. Khan AH, Zou Z, Xiang Y, Chen S and Tian XL*. Conserved signaling pathways genetically associated with longevity across the species.  Biochim Biophys Acta Mol Basis Dis . 2019;1865:1745-1755.

21. Khan AH and Tian XL*. Circadian Amplitude. In: D. Gu and M. E. Dupre, eds.  Encyclopedia of Gerontology and Population Aging Cham: Springer International Publishing; 2019: 1-9.

22. Duan J, Li J, Chen GL, Ge Y, Liu J, Xie K, Peng X, Zhou W, Zhong J, Zhang Y, Xu J, Xue C, Liang B, Zhu L, Liu W, Zhang C, Tian XL, Wang J, Clapham DE, Zeng B, Li Z and Zhang J. Cryo-EM structure of TRPC5 at 2.8-A resolution reveals unique and conserved structural elements essential for channel function.  Sci Adv . 2019;5:eaaw7935.

23. 张存泰, 陶军, 田小利, 洪华山 中华医学会老年医学分会心血管学组. 血管衰老临床评估与干预中国专家共识(2018). 中华老年病研究电子杂志. 2019;0.

24. 李扬，闫晗，田小利. 转录组学结合全基因组关联分析鉴定ROR1为冠心病新易感基因. 中华老年医学杂志. 2019;38.

25. Zhao X, Liu X, Zhang A, Chen H, Huo Q, Li W, Ye R, Chen Z, Liang L, Liu QA, Shen J, Jin X, Li W, Nygaard M, Liu X, Hou Y, Ni T, Bolund L, Gottschalk W, Tao W, Gu J, Tian XL, Yang H, Wang J, Xu X, Lutz MW, Min J, Zeng Y and Nie C. The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese.  Aging (Albany NY). 2018;10:1206-1222.

26. Zeng Y, Nie C, Min J, Chen H, Liu X, Ye R, Chen Z, Bai C, Xie E, Yin Z, Lv Y, Lu J, Li J, Ni T, Bolund L, Land KC, Yashin A, O'Rand AM, Sun L, Yang Z, Tao W, Gurinovich A, Franceschi C, Xie J, Gu J, Hou Y, Liu X, Xu X, Robine JM, Deelen J, Sebastiani P, Slagboom E, Perls T, Hauser E, Gottschalk W, Tan Q, Christensen K, Shi X, Lutz M, Tian XL*, Yang H and Vaupel J. Sex Differences in Genetic Associations With Longevity.  JAMA Netw Open . 2018;1:e181670.

27. Song C, Yan H, Wang H, Zhang Y, Cao H, Wan Y, Kong L, Chen S, Xu H, Pan B, Zhang J, Fan G, Xin H, Liang Z, Jia W and Tian XL*. AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucose metabolism.  J Genet Genomics . 2018;45:111-120.

28. Lyu G, Guan Y, Zhang C, Zong L, Sun L, Huang X, Huang L, Zhang L, Tian XL, Zhou Z and Tao W. TGF-beta signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging.  Nature communications . 2018;9:2560.

29. Liu ZZ, Wang ZL, Choi TI, Huang WT, Wang HT, Han YY, Zhu LY, Kim HT, Choi JH, Lee JS, Kim HG, Zhao J, Chen Y, Lu Z, Tian XL, Pan BX, Li BM, Kim CH and Xu HA. Chd7 Is Critical for Early T-Cell Development and Thymus Organogenesis in Zebrafish.  Am J Pathol . 2018;188:1043-1058.

30. Li Y, Wang DW, Chen Y, Chen C, Guo J, Zhang S, Sun Z, Ding H, Yao Y, Zhou L, Xu K, Song C, Yang F, Zhao B, Yan H, Wang WJ, Wu C, Lu X, Yang X, Dong J, Zheng G, Tian S, Cui Y, Jin L, Liu G, Cui H, Wang S, Jiang F, Wang C, Erdmann J, Zeng L, Huang S, Zhong J, Ma Y, Chen W, Sun J, Lei W, Chen S, Rao S, Gu D, Schunkert H and Tian XL*. Genome-Wide Association and Functional Studies Identify SCML4 and THSD7A as Novel Susceptibility Genes for Coronary Artery Disease.  Arteriosclerosis, thrombosis, and vascular biology . 2018;38:964-975.

31. Han T, Guo M, Gan M, Yu B, Tian XL and Wang JB. TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1.  Autophagy . 2018;14:2035-2048.

32. Chen M, Lyu G, Han M, Nie H, Shen T, Chen W, Niu Y, Song Y, Li X, Li H, Chen X, Wang Z, Xia Z, Li W, Tian XL, Ding C, Gu J, Zheng Y, Liu X, Hu J, Wei G, Tao W and Ni T. 3' UTR lengthening as a novel mechanism in regulating cellular senescence.  Genome Res . 2018. 28(3):285-294.  doi: 10.1101/gr.224451.117.  Online ahead of print.

33. Zhao Y, Yu Y, Shi M, Yang X, Li X, Jiang F, Chen Y and Tian XL*. Association study to evaluate TFPI gene in CAD in Han Chinese.  BMC Cardiovasc Disord . 2017;17:188.

34. Zhao B, Wang S, Chen J, Ji Y, Wang J, Tian XL and Zhi G. Echocardiographic characterization of hypertrophic cardiomyopathy in Chinese patients with myosin-binding protein C3 mutations.  Experimental and therapeutic medicine . 2017;13:995-1002.

35. Song C, Zhang WH, Wang XH, Zhang JY, Tian XL, Yin XP and Pan BX. Acute stress enhances the glutamatergic transmission onto basoamygdala neurons embedded in distinct microcircuits.  Molecular brain . 2017;10:3.

36. 李扬，杨熹，田小利. 基于改进的DNA连接酶链式反应发现NOD2基因多态性与冠心病的相关性. 中国循环杂志. 2017;32.

37. Zhang T, Yao Y, Wang J, Li Y, He P, Pasupuleti V, Hu Z, Jia X, Song Q, Tian XL, Hu C, Chen Q and Wang QK. Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin.  Human molecular genetics . 2016;25:5094-5110.

38. Zeng Y, Nie C, Min J, Liu X, Li M, Chen H, Xu H, Wang M, Ni T, Li Y, Yan H, Zhang JP, Song C, Chi LQ, Wang HM, Dong J, Zheng GY, Lin L, Qian F, Qi Y, Liu X, Cao H, Wang Y, Zhang L, Li Z, Zhou Y, Wang Y, Lu J, Li J, Qi M, Bolund L, Yashin A, Land KC, Gregory S, Yang Z, Gottschalk W, Tao W, Wang J, Wang J, Xu X, Bae H, Nygaard M, Christiansen L, Christensen K, Franceschi C, Lutz MW, Gu J, Tan Q, Perls T, Sebastiani P, Deelen J, Slagboom E, Hauser E, Xu H, Tian XL, Yang H and Vaupel JW. Novel loci and pathways significantly associated with longevity.  Scientific reports . 2016;6:21243.

39. Zeng Y, Chen H, Ni T, Ruan R, Nie C, Liu X, Feng L, Zhang F, Lu J, Li J, Li Y, Tao W, Gregory SG, Gottschalk W, Lutz MW, Land KC, Yashin A, Tan Q, Yang Z, Bolund L, Ming Q, Yang H, Min J, Willcox DC, Willcox BJ, Gu J, Hauser E, Tian XL and Vaupel JW. Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages.  Rejuvenation research . 2016;19:195-203.

40. Ma JF, Yang F, Mahida SN, Zhao L, Chen X, Zhang ML, Sun Z, Yao Y, Zhang YX, Zheng GY, Dong J, Feng MJ, Zhang R, Sun J, Li S, Wang QS, Cao H, Benjamin EJ, Ellinor PT, Li YG and Tian XL*. TBX5 mutations contribute to early-onset atrial fibrillation in Chinese and Caucasians.  Cardiovasc Res . 2016;109:442-50.

41. Li W, Zheng NZ, Yuan Q, Xu K, Yang F, Gu L, Zheng GY, Luo GJ, Fan C, Ji GJ, Zhang B, Cao H and Tian XL*. NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation.  J Mol Med (Berl). 2016;94:993-1002.

42. Jiang F, Yan H, Wu C, Song C, Zhao B, Li Y, Dong J, Zheng GY, Jin LJ, Li XQ, Li WY, Cai J, Yang XC and Tian XL*. A novel block at chromosome 12q24.1 is associated with coronary artery disease in Han Chinese populations.  Pharmacogenet Genomics . 2016;26:497-504.

43. Guo J, Li Y, Ren YH, Sun Z, Dong J, Yan H, Xu Y, Wang DW, Zheng GY, Du J and Tian XL*. Mutant LRP6 Impairs Endothelial Cell Functions Associated with Familial Normolipidemic Coronary Artery Disease.  International journal of molecular sciences . 2016;17(7):1173.  doi: 10.3390/ijms17071173

44. Zeng Y, Chen H, Ni T, Ruan R, Feng L, Nie C, Cheng L, Li Y, Tao W, Gu J, Land KC, Yashin A, Tan Q, Yang Z, Bolund L, Yang H, Hauser E, Willcox DC, Willcox BJ, Tian XL* and Vaupel JW. GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China.  The journals of gerontology . 2015;70:426-33.

45. Xu K, Ma L, Li Y, Wang F, Zheng GY, Sun Z, Jiang F, Chen Y, Liu H, Dang A, Chen X, Chun J and Tian XL*. Genetic and Functional Evidence Supports LPAR1 as a Susceptibility Gene for Hypertension.  Hypertension . 2015;66:641-6.

46. 田小利. 老年医学领域研究进展. 科学观察. 2015;0.

47. Zhao Y, Yu Y, Tian XL, Yang X, Li X, Jiang F, Chen Y and Shi M. Association study to evaluate FoxO1 and FoxO3 gene in CHD in Han Chinese.  PLoS One . 2014;9:e86252.

48. Yang F, Zhou L, Wang Q, You X, Li Y, Zhao Y, Han X, Chang Z, He X, Cheng C, Wu C, Wang WJ, Hu FY, Zhao T, Li Y, Zhao M, Zheng GY, Dong J, Fan C, Yang J, Meng X, Zhang Y, Zhu X, Xiong J, Tian XL* and Cao H. NEXN inhibits GATA4 and leads to atrial septal defects in mice and humans.  Cardiovasc Res . 2014;103:228-37.

49. Tian XL* and Li Y. Endothelial cell senescence and age-related vascular diseases.  J Genet Genomics . 2014;41:485-95.

50. 曾毅, 程令国, 阮荣平, 陈华帅, 李建新, 张风雨, 陶伟, 顾军 and 田小利. 环境与遗传因素交互作用对老龄健康的影响＊--相关前期研究综述. 医学与哲学：人文社会医学版. 2014;35.

51. Zeng Y, Cheng L, Zhao L, Tan Q, Feng Q, Chen H, Shen K, Li J, Zhang F, Cao H, Gregory SG, Yang Z, Gu J, Tao W, Tian XL and Hauser ER. Interactions between social/ behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China.  BMC geriatrics . 2013;13:91.

52. Yang F, Wu M, Li Y, Zheng GY, Cao HQ, Sun W, Yang R, Zhang H, Sheng YH, Kong XQ, Tian XL and Zhou L. Mutation p.S335X in GATA4 reduces its DNA binding affinity and enhances cell apoptosis associated with ventricular septal defect.  Current molecular medicine . 2013;13:993-9.

53. Wu C, Yan H, Sun J, Yang F, Song C, Jiang F, Li Y, Dong J, Zheng GY, Tian XL* and Cao H. NEXN is a novel susceptibility gene for coronary artery disease in Han Chinese.  PLoS One . 2013;8:e82135.

54. Wang WJ, Han P, Zheng J, Hu FY, Zhu Y, Xie JS, Guo J, Zhang Z, Dong J, Zheng GY, Cao H, Liu TS, Fu Q, Sun L, Yang BB and Tian XL*. Exon 47 skipping of fibrillin-1 leads preferentially to cardiovascular defects in patients with thoracic aortic aneurysms and dissections.  J Mol Med (Berl). 2013;91:37-47.

55. Hu FY, Wu C, Li Y, Xu K, Wang WJ, Cao H and Tian XL*. AGGF1 is a novel anti-inflammatory factor associated with TNF-alpha-induced endothelial activation.  Cell Signal . 2013;25:1645-53.

56. Zhao L, Yang F, Xu K, Cao H, Zheng GY, Zhang Y, Li J, Cui H, Chen X, Zhu Z, He H, Mo X, Kennedy BK, Suh Y, Zeng Y and Tian XL*. Common genetic variants of the beta2-adrenergic receptor affect its translational efficiency and are associated with human longevity.  Aging cell . 2012;11:1094-101.

57. Gombar S, Jung HJ, Dong F, Calder B, Atzmon G, Barzilai N, Tian XL, Pothof J, Hoeijmakers JH, Campisi J, Vijg J and Suh Y. Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing.  BMC Genomics . 2012;13:353.

58. Dong W, Yang Z, Yang F, Wang J, Zhuang Y, Xu C, Zhang B, Tian XL and Liu D. Suppression of Rap1 impairs cardiac myofibrils and conduction system in zebrafish.  PLoS One . 2012;7:e50960.

59. Chen LY, Zhao WH, Tian W, Guo J, Jiang F, Jin LJ, Sun YX, Chen KM, An LL, Li GD, Li Q, Li Y, Wu C, Zhao L, Wang WJ, Zheng GY, Li B, Li XQ, Hu J and Tian XL*. STK39 is an independent risk factor for male hypertension in Han Chinese.  Int J Cardiol . 2012;154:122-7.

60. 赵明，, 朱鲜阳，, 田小利，, 王琦光，, 杨帆，, 吕蓓，, 王红，, 董洁， and 郑谷燕. 法洛四联症患者ZFPM2/FOG2基因编码区突变检测. 中国心血管病研究杂志. 2012;10.

61. Jiang F, Dong Y, Wu C, Yang X, Zhao L, Guo J, Li Y, Dong J, Zheng GY, Cao H, Jin L, Ren Y, Cheng W, Li W, Tian XL* and Li X. Fine mapping of chromosome 3q22.3 identifies two haplotype blocks in ESYT3 associated with coronary artery disease in female Han Chinese.  Atherosclerosis . 2011;218:397-403.

62. Fang H, Chen M, Ding Y, Shang W, Xu J, Zhang X, Zhang W, Li K, Xiao Y, Gao F, Shang S, Li JC, Tian XL, Wang SQ, Zhou J, Weisleder N, Ma J, Ouyang K, Chen J, Wang X, Zheng M, Wang W, Zhang X and Cheng H. Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals.  Cell Res . 2011;21:1295-304.

63. Zeng Y, Cheng L, Chen H, Cao H, Hauser ER, Liu Y, Xiao Z, Tan Q, Tian XL* and Vaupel JW. Effects of FOXO genotypes on longevity: a biodemographic analysis.  The journals of gerontology . 2010;65:1285-99.

64. Li Y, Wang WJ, Cao H, Lu J, Wu C, Hu FY, Guo J, Zhao L, Yang F, Zhang YX, Li W, Zheng GY, Cui H, Chen X, Zhu Z, He H, Dong B, Mo X, Zeng Y and Tian XL*. Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations.  Human molecular genetics . 2009;18:4897-904.

65. Zhang T, Yong SL, Tian XL and Wang QK. Cardiac-specific overexpression of SCN5A gene leads to shorter P wave duration and PR interval in transgenic mice.  Biochem Biophys Res Commun . 2007;355:444-50.

66. Tian XL, Cheng Y, Zhang T, Liao ML, Yong SL and Wang QK. Optical mapping of ventricular arrhythmias in LQTS mice with SCN5A mutation N1325S.  Biochem Biophys Res Commun . 2007;352:879-83.

67. Tian XL and Wang QK. Generation of transgenic mice for cardiovascular research.  Methods Mol Med . 2006;129:69-81.

68. Tian XL, Yong SL, Wan X, Wu L, Chung MK, Tchou PJ, Rosenbaum DS, Van Wagoner DR, Kirsch GE and Wang Q. Mechanisms by which SCN5A mutation N1325S causes cardiac arrhythmias and sudden death in vivo.  Cardiovasc Res . 2004;61:256-67.

69. Tian XL, Pinto YM, Costerousse O, Franz WM, Lippoldt A, Hoffmann S, Unger T and Paul M. Over-expression of angiotensin converting enzyme-1 augments cardiac hypertrophy in transgenic rats.  Human molecular genetics . 2004;13:1441-50.

70. Tian XL, Kadaba R, You SA, Liu M, Timur AA, Yang L, Chen Q, Szafranski P, Rao S, Wu L, Housman DE, DiCorleto PE, Driscoll DJ, Borrow J and Wang Q. Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome.  Nature . 2004;427:640-5.

71. Pokharel S, van Geel PP, Sharma UC, Cleutjens JP, Bohnemeier H, Tian XL, Schunkert H, Crijns HJ, Paul M and Pinto YM. Increased myocardial collagen content in transgenic rats overexpressing cardiac angiotensin-converting enzyme is related to enhanced breakdown of N-acetyl-Ser-Asp-Lys-Pro and increased phosphorylation of Smad2/3.  Circulation . 2004;110:3129-35.

72. Tian XL* and Paul M. Species-specific splicing and expression of angiotensin converting enzyme.  Biochem Pharmacol . 2003;66:1037-44.

73. Archacki SR, Angheloiu G, Tian XL, Tan FL, DiPaola N, Shen GQ, Moravec C, Ellis S, Topol EJ and Wang Q. Identification of new genes differentially expressed in coronary artery disease by expression profiling.  Physiol Genomics . 2003;15:65-74.

74. Kang N, Walther T, Tian XL, Bohlender J, Fukamizu A, Ganten D and Bader M. Reduced hypertension-induced end-organ damage in mice lacking cardiac and renal angiotensinogen synthesis.  J Mol Med (Berl). 2002;80:359-66.

75. Chen LY, Chen X, Tian XL and Yu XH. Effects of tetrandrine on calcium transport, protein fluorescences and membrane fluidity of sarcoplasmic reticulum.  Br J Pharmacol . 2000;131:530-6.

76. 陈兰英, 方福德, 田小利, 刘红 and 赵淑华. Studies on renin-2 gene in transgenic rats. 中华医学杂志：英文版. 1999;0.

77. Sugimura K, Tian XL, Hoffmann S, Ganten D and Bader M. Alternative splicing of the mRNA coding for the human endothelial angiotensin-converting enzyme: a new mechanism for solubilization.  Biochem Biophys Res Commun . 1998;247:466-72.

78. 何泉, 田小利, 戴蕴平, 陈永福, 陈兰英 and 刘力生. MLC_2-糜酶融合基因转基因小鼠的建立. 中国医学科学院学报. 1997;19:1.

79. 何泉, 陈兰英, 田小利, 赵淑华 and 姜立群. 原核注射产生转基因小鼠中的缺失整合. 基础医学与临床. 1997;17:4.

80. 周哓霞, 陈兰英 and 田小利. 肾素基因在乳鼠心肌与非心肌细胞的转录表达及调节. 中国高血压杂志. 1995;3.

81. 田小利，杜建生. 卒中型高血压大鼠心肌线粒体Ca^2+,Mg^2+-ATPase及膜流动. 基础医学与临床. 1995;15.

82. 田小利，陈兰英. 转基因动物研究中存在问题. 生物工程进展. 1995;15.

83. 陈兰英，田小利. 转基因的整合与表达检测技术. 细胞生物学杂志. 1995;17.

84. 陈兰英, 田小利 and 宋来凤. BIOCHEMICAL AND BIOPHYSICAL CHARACTERISTICS OF MITOCHONDRIA IN THE HYPERTROPHIC HEARTS FROM HYPERTENSIVE RATS. 中华医学杂志：英文版. 1995;0.

85. 田小利, 刘红, 陈兰英 and 方福德. 有效移植转基因后的受精卵. 基础医学与临床. 1994;14.

86. 田小利, 陈兰英 and 方福德. 小鼠肾素—Ⅱ全长基因的物理图谱. 中国医学科学院学报. 1994;16.

87. 田小利，徐堤. 磁珠法分离特异mRNA. 生物化学与生物物理进展. 1993;20.

88. 田小利，陈兰英. 转基因动物和高血压研究. 中国循环杂志. 1993;8.

89. 田小利，陈兰英. 转基因动物的应用及前景. 细胞生物学杂志. 1993;15.

90. Chen LY, Tian XL and Yang B. A study on the inhibition of rat myocardium glutathione peroxidase and glutathione reductase by moniliformin.  Mycopathologia . 1990;110:119-24.

专著及章节

1. Xiao-Li Tian (2019), Section editor for “ Cardiovascular Diseases ”. In: Danan Gu, and Matthew E. Dupre. (eds) “Encyclopedia of Gerontology and Population Aging” Springer, Cham.

2. Sun Z., Khan A.H., Tian XL. (2019)  Atherosclerosis . In: Gu D., Dupre M. (eds) Encyclopedia of Gerontology and Population Aging. Springer, Cham

3. Khan A.H., Tian XL. (2019)  Circadian Amplitude . In: Gu D., Dupre M. (eds) Encyclopedia of Gerontology and Population Aging. Springer, Cham

4. Saeed M., Tian XL. (2019)  Circulatory System . In: Gu D., Dupre M. (eds) Encyclopedia of Gerontology and Population Aging. Springer, Cham

5. Saeed M., Tian XL. (2019)  Cardiovascular System . In: Gu D., Dupre M. (eds) Encyclopedia of Gerontology and Population Aging. Springer, Cham

6.《血管生物学》，参与编写， 2015

7.《遗传性心律失常》，副主编（主编：浦介麟、张开滋、李翠兰、洪奎），人民卫生出版社， 2011

8.《肥厚性心肌病》，参与者（主编：姜藤勇），人民卫生出版社， 2010

9.《转基因动物的原理、技术及应用》，主编：田小利、陈兰英和扈荣良。长春科技出版社1995。

10. Chapter 95: “Molecular Genetics”, Qing Wang,      Bond M, Elston RC, Tian X. 《Textbook of Cardiovascular      Medicine》, Eric J. TOpol, Lippincott Williams and      Wilkins Publishers 2001

11. Chapter 98: “Transgenic model and      cardiovascular diseases”《Textbook of Cardiovascular      Medicine》, Eric J. TOpol, Lippincott Williams and      Wilkins Publishers 2001

13. Chapter 5: “Generation of Transgenic Mice for      Cardiovascular Research” in Cardiovascular Disease: Methods and Protocols,      Volume 2, Molecular Medicine》，Qing K.Wang。 Humana Press 2006

14. 第九章（第三篇）：“酶活力及其动力学常数的测定”《现代医学实验技巧全书》，主编方福德、周吕、丁濂和张德昌。北京医科大学中国协和医科大学联合出版社  1995。

15. 第16章：“心血管疾病与基因治疗”康宁玲、田小利和丁金凤。《人类基因治疗》，主编刘德培。北京医科大学中国协和医科大学联合出版社 1995.  

国际会议发言及特邀报告：

1. “Exome-seq identifies signaling pathways for human longevity”.Duke University, U.S.A. Feb. 26-28, 2015

2. “Genetic determinants of aging and vascular aging”, Cold Spring Harbor Conference Asia, Sept. 9-13, Suzhou, 2013.

3. “Molecular Basis of Vascular Aging”, Sino-German symposium on melecular systems approaches to aging, May 20-24, Shanghai, China, 2013

4. “Genetics of therasic arotic anuerysm and dissection”, Council on Basic Cardiovascular Sciences 2012 Scientific Seesions, July 23-26, 2012, New Orleans, Louisiana.

5. “Genetics, enviroments, and longevity”. Duke University, July 18. 17, 2011

6. 1）“AF Mechanisms Learned From Bench”；2）“Basic Mechanisms for Cardiac Arrhythmias”. The 3^rd Asia-Pacific Heart Rhythm Society Scientific Session In Conjunction with 6^th Asia-Pacific Atrial Fibrillation Symposium （Oct. 28-30, 2010 ICC Jeju, Jeju Island, Korea）：

7. “Genome-wide association study: current status and future in translational medicine in cardiovascular diseases”. International Efforts in Translational Medicine （Sept. 17-19, 2010, Sydney, Australia）

8. “Foxo family and human longevity”, Duke University, Feb. 17, 2009

9. “Genetics of cardiac arrhythmia”, Pfizer, Boston, March 20, 2008

10.  “Chromosome abnormalities and cardiovascular diseases”, March 12, 2005, Invitrogen

11. “Abnormal Calcium Handling Involved in Arrhythmogenesis in Transgenic Mouse with Selective Cardiac Expression of Long QT3 Mutation (N1325S)”. North American Society of Pacing and Electrophysiology (NASPE), 24^th Annual Scientific Session, San Francisco, California, USA, May 19-22, 2004.

12. “Fast fluorescence imaging reveals mechanism of spontaneous ventricular arrhythmias in transgenic mice with long QT syndrome type 3 (LQT3) mutation”. North American Society of Pacing and Electrophysiology (NASPE), 24^th Annual Scientific Session, Washington DC, USA, May 14-17, 2003:

13. American Heart Association Scientific Session, Chicago, Illinois, USA. Nov. 17-20, 2002: “Long QT3 Mutation, N1325S, Causes Electrophysiological Remodeling in Transgenic Mouse Model” in the 75^th Anniversary Featured Research Session: Novel Insight into Mechanisms of Sudden Death.

14. American Heart Association Scientific Session, Anaheim, California, USA. Nov. 10-14, 2001: “Transgenic model for Long QT and Sudden Cardiac Death” in Insight into Arrhythmogenesis From Novel Animal and Genetic Models.

15. American Heart Association Scientific Session, Anaheim, California, USA. Nov. 10-14, 2001: “Sudden Cardiac Death in long QT transgenic mice” in Late Breaking News Session.

国际会议主持：

1. Council on Basic Cardiovascular Sciences 2012 Scientific Seesions, July 23-26, 2012, New Orleans, Louisiana （Chair for two sessions）

2. 4th Asian Aging Research Association Forum, Nov 7-9, Beijing, 2014.(主席，组织者)

3. Cold Spring Harbor Conference Asia, Sept. 9-13, Suzhou, 2013.

4. Council on Basic Cardiovascular Sciences 2012 Scientific Seesions, July 23-26, 2012, New Orleans, Louisiana (Chair and Speaker)

组织国内会议（主席团成员、特邀报告等略）

102期国家自然基金委“双清论坛”（主席，报告）

Current Concept on Aging Beijing 2013（主席，报告）

2016年全国老年基础与转化医学论坛（主席，报告）