Aging and Vascular Diseases

Principal Investigator

Xiao-Li Tian

Professor

Contact information

Room B311, Science & Life Building, Nanchang University, 999 Xuefu Avenue, Nanchang, Jiangxi, China

Email: tianxiaoli@ncu.edu.cn

Biography

Education:

 1999-2004, Post doctorate, Postdoc in Centre for Molecular Genetics and Dept. of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, USA.

 1994-1999, Ph. D. Molecular Biology and Pharmacology, Free University of Berlin (Cum laude), Berlin, Germany.

 1991-1994, M.Sc. Molecular Cardiology and Biochemistry, Peking Union Medical College, Beijing, China.

 1983-1987, B.Sc. Biochemistry, Wuhan University, Wuhan, China.

Experiences

 2016- present: Professor, School of Life Science, and Director, Human Aging Research Institute, Nanchang University (served as Dean from 2015-2023)

 2006-2016: Professor, Principal Investigator, Human Population Genetics, Institute of Molecular Medicine, Beijing University, China.

 2004-2006: Staff Research Associate in Centre for Molecular Genetics and Department of Molecular Cardiology, Lerner Research. Institute, Cleveland Clinic Foundation, USA.

 1994-1999: Ph.D. student program in Hypertension Research, Max-Delbrück Centre for Molecular Medicine, Berlin, Germany.

 1993-1994: Assistant Professor in Department of Biochemistry. Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing

 1987-1993: Junior researcher in the Dept. of Biochemistry. Cardiovascular Institute and Fuwai Hospital, same as above

Research Interests

Our Lab focuses on identification of aging-related genes and assessment of their contributions to aging-associated cardiovascular diseases by multiple omics tools in human population-based studies (centenarians and patients with cardiovascular diseases). We are interested in understanding the mechanisms of programmed endothelial cell senescence induced by clinically relevant pathological stimuli and the potential translational uses of these knowledge.

Research Grants

1. 2024.1-2026.12: “Mechanisms underlying centenarians escapes from coronary artery diseases” (PI), Key Program, by National Natural Science Foundation of China（81630034）, 2.2M RMB

2. 2023.1-2026.12: Mechanism of Organ and Tissue Aging Sequence Affecting Sub-Health and Disease, Key Research and Development Plan of the Ministry of Science and Technology, Project Number: 2023YFC3603301. 1.85M RMB

3. 2019.1-2023.12: The effect and intervention of nutrition and sport on elderly population (Chief Scientist). The National Key Research and Development Program of China (2020YFC2002900). 17.2m RMB

4. 2019.1-2023.12: Personalized treatment of coronary artery diseases based individual genetic variants. The Key Research and Development Program of Jiangxi Province (20192ACB70002) 1.0m RMB

5. 2018.1-2020.12: Genetic mechanisms underlying escape of centenarians from coronary artery diseases. The Key Program of Jiangxi Province (20181ACB20017). 1.0m RMB

6. 2018.1-now: Jiangxi Key Laboratory for Human Aging (20181BCD40001), 0.5m RMB

7. 2017.1-2022.12: “Mechanism by which the genes associated with human aging modulate vascular endothelial cell senescence” (PI), Key Program, by National Natural Science Foundation of China（81630034）, 2.75M RMB

8. 2013.1-2017.12: “Fundamental Biology of Vascular aging and related diseases”, (Chief Scientist), National Key Basic Research Program (973 program), by Ministry of Science and Technology PRC （2013CB530700）, 32M RMB

9. 2012.1-2016.12: “Mechanisms for early response and repair of vascular damage” (PI), Key Program, by National Natural Science Foundation of China（81130003）, 2.85M RMB

10. 2011.1-2013.12: “Identification of a novel isoform of AGGF1” (PI), General Program, by National Natural Science Foundation of China” (81070262), 385K RMB

11. 2007.1-2011.12: Genetics of ischemic heart disease (PI) in 973 program “Mechanisms of critical cardiac diseases and preventive strategies”, by Ministry of Science and Technology PRC （2007CB512103）, 7.6M RMB

12. 2007.1-2010.12: The genetics of congenital vascular disease (PI), Key Program, by National Natural Science Foundation of China（30730047）, 1.66M RMB

Publications (International Journals)

1. Zhu YZ, Liu JK, Li XE, Yu ZP, Yang LQ, Wan Q, Zhao Y, Saeed M, Wu AD, Tian XL* Genome-wide search links senescence-associated secretory proteins with susceptibility for coronary artery disease in mouse and human. Gerontol A Biol Sci Med Sci. 2024 Feb 28:glae070. doi: 10.1093/gerona/glae070. Online ahead of print. MID: 38416803

2. Li A, Yan J, Zhao Y, Yu Z, Tian S, Khan AH, Zhu Y, Wu A, Zhang C, Tian XL*. Vascular Aging: Assessment and Intervention. Clin Interv Aging. 2023 Aug 17;18:1373-1395. doi: 10.2147/CIA.S423373. eCollection 2023.

3. Zeng Y, Chen H, Liu X, Song Z, Yao Y, Lei X, Lv X, Cheng L, Chen Z, Bai C, Yin Z, Lv Y, Lu J, Li J, Land KC, Yashin A, O'Rand AM, Sun L, Yang Z, Tao W, Gu J, Gottschalk W, Tan Q, Christensen K, Hesketh T, Tian XL, Yang H, Egidi V, Caselli G, Robine JM, Wang H, Shi X, Vaupel JW, Lutz MW, Nie C, Min J. Genetic associations with longevity are on average stronger in females than in males. Heliyon. 2023 Dec 14;10(1):e23691. doi: 10.1016/j.heliyon.2023.e23691. eCollection 2024 Jan 15. PMID: 38192771

4. Aging Biomarker Consortium, Le Zhang, Jun Guo, Yuehong Liu, Shimin Sun, Baohua Liu, Qi Yang, Jun Tao, Xiao-Li Tian, Jun Pu, Huashan Hong, Miao Wang, Hou-Zao Chen, Jie Ren, Xiaoming Wang, Zhen Liang, Yuan Wang, Kai Huang, Weiqi Zhang, Jing Qu, Zhenyu Ju, Guang-Hui Liu, Gang Pei, Jian Li, Cuntai Zhang (correspondence). A framework of biomarkers for vascular aging: a consensus statement by the Aging Biomarker Consortium. Life Medicine, Volume 2, Issue 4, August 2023, lnad033, https://doi.org/10.1093/lifemedi/lnad033

5. Zhang HJ, Wang BH, Wang X, Huang CP, Xu SM, Wang JL, Huang TE, Xiao WL, Tian XL, Lan XQ, Wang QQ, Xiang Y. Handelin alleviates cachexia- and aging-induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation. J Cachexia Sarcopenia Muscle. 2023 Nov 27. doi: 10.1002/jcsm.13381. Online ahead of print.

6. Xu W, Liu X, Han W, Wu K, Zhao M, Mei T, Shang B, Wu J, Luo J, Lai Y, Yang B, Zhuo Y, Lu L, Liu Y, Tian XL, Zhao L*. Inhibiting HIF-1 signaling alleviates HTRA1-induced RPE senescence in retinal degeneration. Cell Commun Signal. 2023 Jun 14;21(1):134. doi: 10.1186/s12964-023-01138-9.

7. Jie Ren, Moshi Song, Weiqi Zhang, Jian-Ping Cai, Feng Cao, Zhongwei Cao, Piu Chan, Chang Chen , Guobing Chen, Hou-Zao Chen, Jun Chen, Xiao-Chun Chen, Weimin Ci, Bi-Sen Ding , Qiurong Ding, Feng Gao, Shaorong Gao, Jing-Dong J Han, Qi-Yang He, Kai Huang, Zhenyu Ju, Qing-Peng Kong, Ji Li, Jian Li, Jingyi Li, Xin Li, Baohua Liu, Feng Liu, Jun-Ping Liu, Lin Liu, Qiang Liu, Qiang Liu, Xingguo Liu, Yong Liu, Xianghang Luo, Shuai Ma, Xinran Ma, Zhiyong Mao, Jing Nie, Yaojin Peng, Jing Qu, Ruibao Ren, Weihong Song, Zhou Songyang, Liang Sun, Yi Eve Sun, Yu Sun, Mei Tian, Xiao-Li Tian, Ye Tian, Jianwei Wang, Shusen Wang, Si Wang, Wengong Wang, Xia Wang, Xiaoning Wang, Yan-Jiang Wang, Yunfang Wang, Catherine C L Wong, Andy Peng Xiang, Yichuan Xiao, Zhi-Xiong Xiao, Zhengwei Xie, Wei Xiong, Daichao Xu, Ze Yang, Jing Ye, Wei Yu, Rui Yue, Cuntai Zhang, Hongbo Zhang, Liang Zhang, Xinchao Zhang, Yong Zhang, Yun-Wu Zhang, Zhuohua Zhang, Tongbiao Zhao, Yuzheng Zhao, Zhongjun Zhou, Dahai Zhu , Weiguo Zou, Gang Pei, Guang-Hui Liu. The Aging Biomarker Consortium represents a new era for aging research in China. Nat Med. 2023 Jul 19. doi: 10.1038/s41591-023-02444-y. Online ahead of print.

8. Long C, Liu H, Zhan W, Chen L, Yu Z, Tian S, Xiang Y, Chen S*, Tian XL*. Chronological attenuation of NPRA/PKG/AMPK signaling promotes vascular aging and elevates blood pressure. Aging Cell. 2022 Sep;21(9):e13699. doi: 10.1111/acel.13699. Epub 2022 Aug 25.

9. Cai Y, Song W, Li J, Jing Y, Liang C, Zhang L, Zhang X, Zhang W, Liu B, An Y, Li J, Tang B, Pei S, Wu X, Liu Y, Zhuang CL, Ying Y, Dou X, Chen Y, Xiao FH, Li D, Yang R, Zhao Y, Wang Y, Wang L, Li Y, Ma S, Wang S, Song X, Ren J, Zhang L, Wang J, Zhang W, Xie Z, Qu J, Wang J, Xiao Y, Tian Y, Wang G, Hu P, Ye J, Sun Y, Mao Z, Kong QP, Liu Q, Zou W, Tian XL, Xiao ZX, Liu Y, Liu JP, Song M, Han JJ, Liu GH (correspondence). The landscape of aging. Sci China Life Sci. 2022 Dec;65(12):2354-2454. doi: 10.1007/s11427-022-2161-3.

10. Liu H, Liu J, Long C, Chen L, Zhan W, Xiao W, Gong X, Liu M, Tian XL, Chen S. Lack of NPR1 Increases Vascular Endothelial Adhesion through Induction of Integrin Beta 4. Int J Mol Sci. 2022 Oct 20;23(20):12627. doi: 10.3390/ijms232012627.

11. Shuangjin Ding, Jiankun Liu, XiaoRui Han, Wanqiu Ding, Zhirui Liu, Ying Zhu, Wenxing Zhan, Yiqi Wan, Shujie Gai, Junjie Hou, Xiaoxia Wang, Yixia Wu, Andong Wu, Chuan-Yun Li, Zhe Zheng, Xiao-Li Tian*, Huiqing Cao* ICAM-1-Related Noncoding RNA accelerates atherosclerosis by amplifying NF-κB signaling, J Mol Cell Cardiol. 2022 Sep;170:75-86. doi: 10.1016/j.yjmcc.2022.06.001. Epub 2022 Jun 14.

12. Wan Y, Liu Z, Wu A, Khan AH, Zhu Y, Ding S, Li X, Zhao Y, Dai X, Zhou J, Liu J, Li Y, Gong X, Liu M, Tian XL*. Hyperglycemia Promotes Endothelial Cell Senescence through AQR/PLAU Signaling Axis. Int J Mol Sci. 2022 Mar 7;23(5):2879. doi: 10.3390/ijms23052879.

13. Zhang CF, Wang HM, Wu A, Li Y and Tian XL*. FHA domain of AGGF1 is essential for its nucleocytoplasmic transport and angiogenesis. Science China Life sciences. November 2021 Vol.64 No.11: 1884–1894

14. Zhang C, Zhang X, Huang L, Guan Y, Huang X, Tian XL, Zhang L and Tao W. ATF3 drives senescence by reconstructing accessible chromatin profiles. Aging cell. 2021;20:e13315.

15. Sun ZC, Jiang Z, Xu X, Li M, Zeng Q, Zhu Y, Wang S, Li Y, Tian XL* and Hu C*. Fish Paralog Proteins RNASEK-a and -b Enhance Type I Interferon Secretion and Promote Apoptosis. Frontiers in immunology. 2021;12:762162.

16. Li Y, Yan H, Guo J, Han Y, Zhang C, Liu X, Du J and Tian XL*. Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease. Cardiovasc Res. 2021;117:240-255.

17. Ying Zhu, Yu Liang, Abdul Haseeb Khan, Minghua Dong, Yiqi Wan, Zhichao Sun, Yi Zeng, Chao Nie, Xiao-Li Tian*. Allelic distribution of ABO gene in Chinese centenarians. Aging Med (Milton). 2020 Sep 11;3(3):195-204. doi: 10.1002/agm2.12122. eCollection 2020 Sep.

18. Di Yang, Gang Wei, Fen Long, Hongbo Nie, Xiaoli Tian, Lefeng Qu, ShuangXi Wang, Peng Li, Yue Qiu, Yang Wang, Wanjin Hong, Ting Ni, Xinhua Liu, Yi Zhun Zhu. Histone methyltransferase Smyd3 is a new regulator for vascular senescence. Aging Cell. 2020 Aug 11;e13212. doi: 10.1111/acel.13212. Online ahead of print.

19. Yao Y, Jiang C, Wang F, Yan H, Long D, Zhao J, Wang J, Zhang C, Li Y, Tian X, Wang QK, Wu G, Zhang Z. Integrative Analysis of miRNA and mRNA Expression Profiles Associated With Human Atrial Aging. Front Physiol. 2019 Sep 19;10:1226. doi: 10.3389/fphys.2019.01226. eCollection 2019. PMID: 31607954 Free PMC Article

20. Yang Li, Han Yan, Jian Guo, Yingchun Han, Cuifang Zhang, Xiuying Liu, Jie Du, and Xiao-Li Tian* Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease, Cardiovascular Research, 2019 (accepted)

21. Huimin Li, Xinhui Wang, Xinyue Lu, Hongxin Zhu, Sheng Li, Shiwei Duan, Xinzhi Zhao, Fuquan Zhang, Gi Alterovitz,Fudi Wang, Qiang Li, Xiao-Li Tian*, Mingqing Xu*. Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice. Aging-US, 2019 (accepted)

22. Duan J, Li J, Chen GL, Ge Y, Liu J, Xie K, Peng X, Zhou W, Zhong J, Zhang Y, Xu J, Xue C, Liang B, Zhu L, Liu W, Zhang C, Tian XL, Wang J, Clapham DE, Zeng B, Li Z, Zhang J. Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function. Sci Adv. 2019 Jul 24;5(7): eaaw7935. doi: 10.1126/sciadv.aaw7935. eCollection 2019 Jul. PMID: 31355338.

23. Zhang WH, Liu WZ, He Y, You WJ, Zhang JY, Xu H, Tian XL, Li BM, Mei L, Holmes A, Pan BX. Chronic Stress Causes Projection-Specific Adaptation of Amygdala Neurons via Small-Conductance Calcium-Activated Potassium Channel Downregulation. Biol Psychiatry. 2019 May 15;85(10):812-828. doi: 10.1016/j.biopsych.2018.12.010. Epub 2018 Dec 20. PMID: 30737013

24. Zhang JY, Liu TH, He Y, Pan HQ, Zhang WH, Yin XP, Tian XL, Li BM, Wang XD, Holmes A, Yuan TF, Pan BX. Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner. Biol Psychiatry. 2019 Feb 1;85(3):189-201. doi: 10.1016/j.biopsych.2018.06.019. Epub 2018 Jul 5. PMID: 30060908

25. Abdul Haseeb Khan, Zhiwen Zou, Yang Xiang, Shenghan Chen, Xiao-Li Tian*. Conserved signaling pathways genetically associated with longevity across the species. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2018, doi.org/10.1016/j.bbadis.2018.09.001

26. Han T, Guo M, Gan M, Yu B, Tian XL and Wang JB. TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1. Autophagy. 2018:1-14.

27. Lyu G, Guan Y, Zhang C, Zong L, Sun L, Huang X, Huang L, Zhang L, Tian XL, Zhou Z, Tao W. TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging. Nat Commun. 2018 Jul 2;9(1):2560. doi: 10.1038/s41467-018-04994-z.

28. Zhao X, Liu X, Zhang A, Chen H, Huo Q, Li W, Ye R, Chen Z, Liang L, Liu QA, Shen J, Jin X, Li W, Nygaard M, Liu X, Hou Y, Ni T, Bolund L, Gottschalk W, Tao W, Gu J, Tian XL, Yang H, Wang J, Xu X, Lutz MW, Min J, Zeng Y and Nie C. The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese. Aging (Albany NY). 2018.

29. Zeng Y, Nie C, Min J, Chen H, Liu X, Ye R, Chen Z, Bai C, Xie Y, Yin Z, Lv Y, Lu J, Li J, Ni T, Bolund L, Land KC, Yashin A, O’Rand A, Sun L, Yang Z, Tao W, Gurinovich A, Franceschi C, Xie J, Gu J, Hou Y, Liu X, Xu X, Robine JM, Deelen J, Sebastiani P, Slagboom E, Perls T, Hauser E, Gottschalk W, Tan Q, Christensen K, Shi X, Lutz M, Tian XL*, Yang H and Vaupel J. Sex Differences in Genetic Associations With Longevity. JAMA Network Open. 2018;1 (accepted).

30. Song C, Yan H, Wang HM, Zhang Y, Cao H, Wan Y, Kong L, Chen S, Xu H, Pan BX, Zhang J, Fan GH, Xin HB, Liang Z, Jia W, Tian XL*. AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucose metabolism. J Genet Genomics. 2018 Feb 14. pii: S1673-8527(18)30021-3. doi: 10.1016/j.jgg.2017.11.007 [Epub ahead of print] PMID: 29502958

31. Li Y, Wang DW, Chen Y, Chen C, Guo J, Zhang S, Sun Z, Ding H, Yao Y, Zhou L, Xu K, Song C, Yang F, Zhao B, Yan H, Wang WJ, Wu C, Lu X, Yang X, Dong J, Zheng G, Tian S, Cui Y, Jin L, Liu G, Cui H, Wang S, Jiang F, Wang C, Erdmann J, Zeng L, Huang S, Zhong J, Ma Y, Chen W, Sun J, Lei W, Chen S, Rao S, Gu D, Schunkert H and Tian XL*. Genome-Wide Association and Functional Studies Identify SCML4 and THSD7A as Novel Susceptibility Genes for Coronary Artery Disease. Arteriosclerosis, thrombosis, and vascular biology. 2018. Feb 22. pii: ATVBAHA.117.310594. doi: 10.1161/ATVBAHA.117.310594. [Epub ahead of print]

32. Chen M, Lyu G, Han M, Nie H, Shen T, Chen W, Niu Y, Song Y, Li X, Li H, Chen X, Wang Z, Xia Z, Li W, Tian XL, Ding C, Gu J, Zheng Y, Liu X, Hu J, Wei G, Tao W and Ni T. 3' UTR lengthening as a novel mechanism in regulating cellular senescence. Genome Res. 2018. Feb 12. doi: 10.1101/gr.224451.117. [Epub ahead of print]

33. Liu ZZ, Wang ZL, Choi TI, Huang WT, Wang HT, Han YY, Zhu LY, Kim HT, Choi JH, Lee JS, Kim HG, Zhao J, Chen Y, Lu Z, Tian XL, Pan BX, Li BM, Kim CH and Xu H. Chd7 Is Critical for Early T-Cell Development and Thymus Organogenesis in Zebrafish. Am J Pathol. 2018. Jan 31. pii: S0002-9440(17) 30669-7. doi: 10.1016/j.ajpath.2017.12.005. [Epub ahead of print]

34. Zhao Y, Yu Y, Shi M, Yang X, Li X, Jiang F, Chen Y and Tian XL*. Association study to evaluate TFPI gene in CAD in Han Chinese. BMC Cardiovasc Disord. 2017;17:188.

35. Zhao B, Wang S, Chen J, Ji Y, Wang J, Tian XL and Zhi G. Echocardiographic characterization of hypertrophic cardiomyopathy in Chinese patients with myosin-binding protein C3 mutations. Experimental and therapeutic medicine. 2017;13:995-1002.

36. Song C, Zhang WH, Wang XH, Zhang JY, Tian XL, Yin XP and Pan BX. Acute stress enhances the glutamatergic transmission onto basoamygdala neurons embedded in distinct microcircuits. Molecular brain. 2017;10:3.

37. Zhang T, Yao Y, Wang J, Li Y, He P, Pasupuleti V, Hu Z, Jia X, Song Q, Tian XL, Hu C, Chen Q and Wang QK. Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin. Human molecular genetics. 2016;25:5094-5110.

38. Zeng Y*, Nie C, Min J, Liu X, Li M, Chen H, Xu H, Wang M, Ni T, Li Y, Yan H, Zhang JP, Song C, Chi LQ, Wang HM, Dong J, Zheng GY, Lin L, Qian F, Qi Y, Liu X, Cao H, Wang Y, Zhang L, Li Z, Zhou Y, Wang Y, Lu J, Li J, Qi M, Bolund L, Yashin A, Land KC, Gregory S, Yang Z, Gottschalk W, Tao W, Wang J, Wang J, Xu X, Bae H, Nygaard M, Christiansen L, Christensen K, Franceschi C, Lutz MW, Gu J, Tan Q, Perls T, Sebastiani P, Deelen J, Slagboom E, Hauser E, Xu H, Tian XL*, Yang H* and Vaupel JW. Novel loci and pathways significantly associated with longevity. Scientific reports. 2016;6:21243.

39. Zeng Y*, Chen H, Ni T, Ruan R, Nie C, Liu X, Feng L, Zhang F, Lu J, Li J, Li Y, Tao W, Gregory SG, Gottschalk W, Lutz MW, Land KC, Yashin A, Tan Q, Yang Z, Bolund L, Ming Q, Yang H, Min J, Willcox DC, Willcox BJ, Gu J, Hauser E, Tian XL* and Vaupel JW. Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages. Rejuvenation research. 2016;19:195-203.

40. Ma JF, Yang F, Mahida SN, Zhao L, Chen X, Zhang ML, Sun Z, Yao Y, Zhang YX, Zheng GY, Dong J, Feng MJ, Zhang R, Sun J, Li S, Wang QS, Cao H, Benjamin EJ, Ellinor PT, Li YG* and Tian XL*. TBX5 mutations contribute to early-onset atrial fibrillation in Chinese and Caucasians. Cardiovasc Res. 2016;109:442-50.

41. Li W, Zheng NZ, Yuan Q, Xu K, Yang F, Gu L, Zheng GY, Luo GJ, Fan C, Ji GJ, Zhang B, Cao H* and Tian XL*. NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation. J Mol Med (Berl). 2016;94:993-1002.

42. Jiang F, Yan H, Wu C, Song C, Zhao B, Li Y, Dong J, Zheng GY, Jin LJ, Li XQ, Li WY, Cai J, Yang XC and Tian XL*. A novel block at chromosome 12q24.1 is associated with coronary artery disease in Han Chinese populations. Pharmacogenet Genomics. 2016;26:497-504.

43. Guo J, Li Y, Ren YH, Sun Z, Dong J, Yan H, Xu Y, Wang DW, Zheng GY, Du J and Tian XL*. Mutant LRP6 Impairs Endothelial Cell Functions Associated with Familial Normolipidemic Coronary Artery Disease. International journal of molecular sciences. 2016;17.

44. Zeng Y*, Chen H, Ni T, Ruan R, Feng L, Nie C, Cheng L, Li Y, Tao W, Gu J, Land KC, Yashin A, Tan Q, Yang Z, Bolund L, Yang H, Hauser E, Willcox DC, Willcox BJ, Tian XL* and Vaupel JW. GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China. The journals of gerontology. 2015;70:426-33.

45. Xu K, Ma L, Li Y, Wang F, Zheng GY, Sun Z, Jiang F, Chen Y, Liu H, Dang A, Chen X, Chun J and Tian XL*. Genetic and Functional Evidence Supports LPAR1 as a Susceptibility Gene for Hypertension. Hypertension. 2015;66:641-6.

46. Zhao Y, Yu Y, Tian XL, Yang X, Li X, Jiang F, Chen Y and Shi M. Association study to evaluate FoxO1 and FoxO3 gene in CHD in Han Chinese. PLoS One. 2014;9:e86252.

47. Yang F, Zhou L, Wang Q, You X, Li Y, Zhao Y, Han X, Chang Z, He X, Cheng C, Wu C, Wang WJ, Hu FY, Zhao T, Li Y, Zhao M, Zheng GY, Dong J, Fan C, Yang J, Meng X, Zhang Y, Zhu X, Xiong J, Tian XL* and Cao H*. NEXN inhibits GATA4 and leads to atrial septal defects in mice and humans. Cardiovasc Res. 2014;103:228-37.

48. Tian XL* and Li Y. Endothelial cell senescence and age-related vascular diseases. J Genet Genomics. 2014;41:485-95.

49. Zeng Y*, Cheng L, Zhao L, Tan Q, Feng Q, Chen H, Shen K, Li J, Zhang F, Cao H, Gregory SG, Yang Z, Gu J, Tao W, Tian XL* and Hauser ER. Interactions between Social/ behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China. BMC geriatrics. 2013;13:91.

50. Yang F, Wu M, Li Y, Zheng GY, Cao H, Sun W, Yang R, Zhang H, Sheng Y, Kong X, Tian XL and Zhou L. Mutation p.S335X in GATA4 Reduces its DNA Binding Affinity and Enhances Cell Apoptosis Associated with Ventricular Septal Defect. Current molecular medicine. 2013.

51. Wu C, Yan H, Sun J, Yang F, Song C, Jiang F, Li Y, Dong J, Zheng GY, Tian XL* and Cao H*. NEXN Is a Novel Susceptibility Gene for Coronary Artery Disease in Han Chinese. PLoS One. 2013;8:e82135.

52. Wang WJ, Han P, Zheng J, Hu FY, Zhu Y, Xie JS, Guo J, Zhang Z, Dong J, Zheng GY, Cao H, Liu TS, Fu Q, Sun L, Yang BB* and Tian XL*. Exon 47 skipping of fibrillin-1 leads preferentially to cardiovascular defects in patients with thoracic aortic aneurysms and dissections. J Mol Med (Berl). 2013;91:37-47.

53. Hu FY, Wu C, Li Y, Xu K, Wang WJ, Cao H and Tian XL*. AGGF1 is a novel anti-inflammatory factor associated with TNF-alpha-induced endothelial activation. Cell Signal. 2013;25:1645-53.

54. Zhao L, Yang F, Xu K, Cao H, Zheng GY, Zhang Y, Li J, Cui H, Chen X, Zhu Z, He H, Mo X, Kennedy BK, Suh Y, Zeng Y and Tian XL*. Common genetic variants of the beta2-adrenergic receptor affect its translational efficiency and are associated with human longevity. Aging cell. 2012;11:1094-101.

55. Gombar S, Jung HJ, Dong F, Calder B, Atzmon G, Barzilai N, Tian XL, Pothof J, Hoeijmakers JH, Campisi J, Vijg J and Suh Y. Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing. BMC Genomics. 2012;13:353.

56. Dong W, Yang Z, Yang F, Wang J, Zhuang Y, Xu C, Zhang B, Tian XL* and Liu D. Suppression of Rap1 impairs cardiac myofibrils and conduction system in zebrafish. PLoS One. 2012;7:e50960.

57. Chen LY, Zhao WH, Tian W, Guo J, Jiang F, Jin LJ, Sun YX, Chen KM, An LL, Li GD, Li Q, Li Y, Wu C, Zhao L, Wang WJ, Zheng GY, Li B, Li XQ, Hu J* and Tian XL*. STK39 is an independent risk factor for male hypertension in Han Chinese. Int J Cardiol. 2012;154:122-7.

58. Jiang F, Dong Y, Wu C, Yang X, Zhao L, Guo J, Li Y, Dong J, Zheng GY, Cao H, Jin L, Ren Y, Cheng W, Li W, Tian XL* and Li X*. Fine mapping of chromosome 3q22.3 identifies two haplotype blocks in ESYT3 associated with coronary artery disease in female Han Chinese. Atherosclerosis. 2011;218:397-403.

59. Fang H, Chen M, Ding Y, Shang W, Xu J, Zhang X, Zhang W, Li K, Xiao Y, Gao F, Shang S, Li JC, Tian XL, Wang SQ, Zhou J, Weisleder N, Ma J, Ouyang K, Chen J, Wang X, Zheng M, Wang W, Zhang X and Cheng H. Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals. Cell Res. 2011;21:1295-304.

60. Zeng Y*, Cheng L, Chen H, Cao H, Hauser ER, Liu Y, Xiao Z, Tan Q, Tian XL* and Vaupel JW. Effects of FOXO genotypes on longevity: a biodemographic analysis. The journals of gerontology. 2010;65:1285-99.

61. Li Y, Wang WJ, Cao H, Lu J, Wu C, Hu FY, Guo J, Zhao L, Yang F, Zhang YX, Li W, Zheng GY, Cui H, Chen X, Zhu Z, He H, Dong B, Mo X, Zeng Y* and Tian XL*. Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Human molecular genetics. 2009;18:4897-904.

62. Zhang T, Yong SL, Tian XL and Wang QK. Cardiac-specific overexpression of SCN5A gene leads to shorter P wave duration and PR interval in transgenic mice. Biochem Biophys Res Commun. 2007;355:444-50.

63. Tian XL, Cheng Y, Zhang T, Liao ML, Yong SL and Wang QK. Optical mapping of ventricular arrhythmias in LQTS mice with SCN5A mutation N1325S. Biochem Biophys Res Commun. 2007;352:879-83.

64. Tian XL and Wang QK. Generation of transgenic mice for cardiovascular research. Methods Mol Med. 2006;129:69-81.

65. Tian XL, Yong SL, Wan X, Wu L, Chung MK, Tchou PJ, Rosenbaum DS, Van Wagoner DR, Kirsch GE and Wang Q. Mechanisms by which SCN5A mutation N1325S causes cardiac arrhythmias and sudden death in vivo. Cardiovasc Res. 2004;61:256-67.

66. Tian XL, Pinto YM, Costerousse O, Franz WM, Lippoldt A, Hoffmann S, Unger T and Paul M. Over-expression of angiotensin converting enzyme-1 augments cardiac hypertrophy in transgenic rats. Human molecular genetics. 2004;13:1441-50.

67. Tian XL, Kadaba R, You SA, Liu M, Timur AA, Yang L, Chen Q, Szafranski P, Rao S, Wu L, Housman DE, DiCorleto PE, Driscoll DJ, Borrow J and Wang Q. Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome. Nature. 2004;427:640-5.

68. Pokharel S, van Geel PP, Sharma UC, Cleutjens JP, Bohnemeier H, Tian XL, Schunkert H, Crijns HJ, Paul M and Pinto YM. Increased myocardial collagen content in transgenic rats overexpressing cardiac angiotensin-converting enzyme is related to enhanced breakdown of N-acetyl-Ser-Asp-Lys-Pro and increased phosphorylation of Smad2/3. Circulation. 2004;110:3129-35.

69. Yong S, Tian XL and Wang Q. LQT4 gene: the "missing" ankyrin. Mol Interv. 2003;3:131-6.

70. Tian XL* and Paul M. Species-specific splicing and expression of angiotensin converting enzyme. Biochem Pharmacol. 2003;66:1037-44.

71. Archacki SR, Angheloiu G, Tian XL, Tan FL, DiPaola N, Shen GQ, Moravec C, Ellis S, Topol EJ and Wang Q. Identification of new genes differentially expressed in coronary artery disease by expression profiling. Physiol Genomics. 2003;15:65-74.

72. Kang N, Walther T, Tian XL, Bohlender J, Fukamizu A, Ganten D and Bader M. Reduced hypertension-induced end-organ damage in mice lacking cardiac and renal angiotensinogen synthesis. Journal of molecular medicine. 2002;80:359-66.

73. Wang Q, Bond M, Elston RC and Tian XL. Molecuar Genetics. In: E. J. Topol, ed. Textbook of Cardiovascular Medicine. 2nd ed.: Lippincott Williams and Wikins Publishers; 2001.

74. Chen LY, Chen X, Tian XL and Yu XH. Effects of tetrandrine on calcium transport, protein fluorescences and membrane fluidity of sarcoplasmic reticulum. Br J Pharmacol. 2000;131:530-6.

75. Sugimura K, Tian XL, Hoffmann S, Ganten D and Bader M. Alternative splicing of the mRNA coding for the human endothelial angiotensin-converting enzyme: a new mechanism for solubilization. Biochem Biophys Res Commun. 1998;247:466-72.

76. Chen LY, Tian XL and Yang B. A study on the inhibition of rat myocardium glutathione peroxidase and glutathione reductase by moniliformin. Mycopathologia. 1990;110:119-24.

Community Service

Editorial board: Aging Cell, Molecular Genetics and Genomics, Genes.

Group members

Andong Wu

Lecturer

Contact information

Room B309B, Science & Life Building, Nanchang University, 999 Xuefu Avenue, Nanchang, Jiangxi, China

Email: andongwu@ncu.edu.cn

Tel: 19979111579

Biography

Education:

 2008-2014, Ph. D. Microbiology, Wuhan University, Wuhan ,China.

 2004-2008, B. Sc. Biotechnology, Wuhan University, Wuhan, China.

Experiences

 2018- present: Lecturer, School of Life Science, Human Aging Research Institute, Nanchang University

 2014-2017, R & D manager, Space Science and Technology Institute (Shenzhen).

Research Areas

Interventions of delaying aging through nutrition and exercise.

Publications

1. Zhu YZ, Liu JK, Li XE, Yu ZP, Yang LQ, Wan Q, Zhao Y, Saeed M, Wu AD, Tian XL* Genome-wide search links senescence-associated secretory proteins with susceptibility for coronary artery disease in mouse and human. Gerontol A Biol Sci Med Sci. 2024 Feb 28:glae070. doi: 10.1093/gerona/glae070. Online ahead of print. MID: 38416803

2. Vascular Aging: Assessment and Intervention. Li A, Yan J, Zhao Y, Yu Z, Tian S, Khan AH, Zhu Y, Wu A, Zhang C, Tian XL.Clin Interv Aging. 2023 Aug 17;18:1373-1395. doi: 10.2147/CIA.S423373.

3. Null Function of Npr1 Disturbs Immune Response in Colonic Inflammation During Early Postnatal Stage. Long C, Liu H, Zhan W, Chen L, Wu A, Yang L, Chen S. Inflammation. 2022 Dec;45(6):2419-2432. doi: 10.1007/s10753-022-01702-4.

4. ICAM-1-related noncoding RNA accelerates atherosclerosis by amplifying NF-κB signaling. Ding S, Liu J, Han X, Ding W, Liu Z, Zhu Y, Zhan W, Wan Y, Gai S, Hou J, Wang X, Wu Y, Wu A, Li CY, Zheng Z, Tian XL, Cao H. J Mol Cell Cardiol. 2022 Sep;170:75-86. doi: 10.1016/j.yjmcc.2022.06.001.

5. Hyperglycemia Promotes Endothelial Cell Senescence through AQR/PLAU Signaling Axis. Wan Y, Liu Z, Wu A, Khan AH, Zhu Y, Ding S, Li X, Zhao Y, Dai X, Zhou J, Liu J, Li Y, Gong X, Liu M, Tian XL. Int J Mol Sci. 2022 Mar 7;23(5):2879. doi: 10.3390/ijms23052879.

6. FHA domain of AGGF1 is essential for its nucleocytoplasmic transport and angiogenesis. Zhang CF, Wang HM, Wu A, Li Y, Tian XL. Sci China Life Sci. 2021 Nov;64(11):1884-1894. doi: 10.1007/s11427-020-1844-0.

7. Blood Cell DNA Methylation of Aging-Related Ubiquitination Gene DZIP3 Can Predict the Onset of Early Stage Colorectal Cancer. Quan Y, Liang F, Wu D, Yao X, Hu Z, Zhu Y, Chen Y, Wu A, Tang D, Huang B, Xu R, Lyu Z, Yan Q, Luo L, Ning Z, Li Y, Xiong J. Front Oncol. 2020 Nov 27;10:544330. doi: 10.3389/fonc.2020.544330.

8. Insulin-resistance and depression cohort data mining to identify nutraceutical related DNA methylation biomarker for type 2 diabetes. Liang F, Quan Y, Wu A, Chen Y, Xu R, Zhu Y, Xiong J. Genes Dis. 2020 Jan 27;8(5):669-676. doi: 10.1016/j.gendis.2020.01.013.

9. Identification and Characterization of a Ribose 2'-O-Methyltransferase Encoded by the Ronivirus Branch of Nidovirales. Zeng C, Wu A, Wang Y, Xu S, Tang Y, Jin X, Wang S, Qin L, Sun Y, Fan C, Snijder EJ, Neuman BW, Chen Y, Ahola T, Guo D. J Virol. 2016 Jul 11;90(15):6675-6685. doi: 10.1128/JVI.00658-16.

10. SfDredd, a Novel Initiator Caspase Possessing Activity on Effector Caspase Substrates in Spodoptera frugiperda. Yang Z, Zhou K, Liu H, Wu A, Mei L, Liu Q. PLoS One. 2016 Mar 15;11(3):e0151016. doi: 10.1371/journal.pone.0151016.

11. Coronavirus nsp10/nsp16 Methyltransferase Can Be Targeted by nsp10-Derived Peptide In Vitro and In Vivo To Reduce Replication and Pathogenesis. Wang Y, Sun Y, Wu A, Xu S, Pan R, Zeng C, Jin X, Ge X, Shi Z, Ahola T, Chen Y, Guo D. J Virol. 2015 Aug;89(16):8416-27. doi: 10.1128/JVI.00948-15.

12. Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus. Wu A, Wang Y, Zeng C, Huang X, Xu S, Su C, Wang M, Chen Y, Guo D. Virus Res. 2015 Oct 2;208:56-65. doi: 10.1016/j.virusres.2015.05.018.

13. Hepatitis B virus polymerase suppresses NF-κB signaling by inhibiting the activity of IKKs via interaction with Hsp90β. Liu D, Wu A, Cui L, Hao R, Wang Y, He J, Guo D. PLoS One. 2014 Mar 11;9(3):e91658. doi: 10.1371/journal.pone.0091658.

14. Yeast-based assays for the high-throughput screening of inhibitors of coronavirus RNA cap guanine-N7-methyltransferase. Sun Y, Wang Z, Tao J, Wang Y, Wu A, Yang Z, Wang K, Shi L, Chen Y, Guo D. Antiviral Res. 2014 Apr;104:156-64. doi: 10.1016/j.antiviral.2014.02.002.

15. Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP. Jin X, Chen Y, Sun Y, Zeng C, Wang Y, Tao J, Wu A, Yu X, Zhang Z, Tian J, Guo D. Virus Res. 2013 Sep;176(1-2):45-52. doi: 10.1016/j. virusres.2013.05.001. Epub 2013 May 20.

16. Structure-function analysis of severe acute respiratory syndrome coronavirus RNA cap guanine-N7-methyltransferase. Chen Y, Tao J, Sun Y, Wu A, Su C, Gao G, Cai H, Qiu S, Wu Y, Ahola T, Guo D. J Virol. 2013 Jun;87(11):6296-305. doi: 10.1128/JVI.00061-13.

17. Short peptides derived from the interaction domain of SARS coronavirus nonstructural protein nsp10 can suppress the 2'-O-methyltransferase activity of nsp10/nsp16 complex. Ke M, Chen Y, Wu A, Sun Y, Su C, Wu H, Jin X, Tao J, Wang Y, Ma X, Pan JA, Guo D. Virus Res. 2012 Aug;167(2):322-8. doi: 10.1016/j.virusres.2012.05.017.

18. Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex. Chen Y, Su C, Ke M, Jin X, Xu L, Zhang Z, Wu A, Sun Y, Yang Z, Tien P, Ahola T, Liang Y, Liu X, Guo D. PLoS Pathog. 2011 Oct;7(10):e1002294. doi: 10.1371/journal.ppat.1002294.

19. 营养和运动对血管亚健康的精准干预，吴安东，董家仪，吴方，季小茹，裘嘉昱，陈佳坤，余鹏，宋安琪，田小利。中国临床保健杂志. 2022,25(06)。

20. 冠心病的遗传机制，吴安东，刘建坤，赵雅，KHAN Abdul Haseeb，廖立勇，田小利。中国科学:生命科学. 2022,52(02)。

21. 血管衰老及心血管疾病，赵雅，吴安东，廖立勇，刘曼，龚雪婷，田小利。中国科学:生命科学. 2022,52(02)。

22. 细胞衰老及通讯研究，张悦，朱元正，SAEED Muhammad，吴安东，胡成钰，田小利。中国基础科学. 2021,23(05)。